On the PC create/set Environment Variable HOME=<path without any spaces>
e.g. HOME=c:\users\szotkoma\home
restart computer > start Spotfire Analyst > Revvity Signals > update dependencies
There is an official support solution, I haven't tried it: https://support.revvitysignals.com/hc/en-us/articles/4408235352980-How-to-set-a-custom-library-path-for-TIBCO-Enterprise-Runtime-for-R-TERR